New and persistent controlled substance use among patients undergoing mastectomy and reconstructive surgery

Prolonged use of controlled substances can place patients at increased risk dependence and complications. Women who have mastectomy reconstructive surgery (M + R) may be vulnerable to becoming new persistent users (NPUs) opioid sedative-hypnotic medications. Using the MarketScan health-care claims database, we identified opioid- sedative-hypnotic-naïve women had M R from 2008 2017. filled ≥ 1 peri-operative prescription 2 post-operative prescriptions within one year after were classified as NPUs. Univariate multivariable logistic regression analyses used estimate rates predictive factors. Risk summary scores created based on sum associated We evaluated 23,025 opioid-naïve 25,046 women. found that 17,174 a prescription, those, 2962 (17.2%) became NPUs post-operatively. Additionally, 9426 1612 (17.1%) Development was with age ≤ 49 [OR 1.77 (95% CI 1.40–2.24)] 50–64 [1.60 (1.27–2.03)] compared 65; Medicaid insurance [2.34 (1.40–3.90)]; southern residence [1.42 (1.22–1.64)]; breast cancer diagnosis [2.24 (1.28–3.91)]; chemotherapy [2.17 (1.94–2.42)]. NPU higher score. 3 these factors three times more likely become than 0 or [2.94 (2.51–3.43)]. Comparable findings seen regarding use. are developing both A patient’s an increases their number increases. Non-pharmacologic strategies needed manage pain anxiety following cancer-related surgery.